Diethylcarbamazine is a medication primarily used in the treatment of lymphatic filariasis and onchocerciasis. It has microfilaricidal and macrofilaricidal properties, acting by paralyzing and killing the parasitic worms causing these diseases.

Diethylcarbamazine is prescribed to treat filariasis, which includes lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. Diethylcarbamazine is a drug prescribed for filariasis treatment, which includes lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. It can also be utilized to prevent loiasis in individuals with a high risk.

Diethylcarbamazine is prescribed for individuals afflicted with specific filarial conditions such as lymphatic filariasis due to Wuchereria bancrofti, Brugia malayi, or Brugia timori, as well as for loiasis and tropical pulmonary eosinophilia. The WHO suggests the use of diethylcarbamazine for individuals with microfilariae infections from filarial parasites and to manage infection transmission in filariasis-prevalent regions.

Contraindications include a history of heart issues, gastrointestinal problems, and allergies. Diethylcarbamazine should not be administered to patients at risk of experiencing the Mazzotti reaction if they have onchocerciasis.

Diethylcarbamazine inhibits the metabolism of arachidonic acid in microfilariae. Diethylcarbamazine inhibits arachidonic acid metabolism in microfilariae, rendering them more vulnerable to innate immune responses without directly causing their death.

Some of the brand names are Hetrazan, Carbilazine, Caricide, Cypip, Ethodryl, Notézine, Spatonin, Filaribits, Banocide Forte, and Eofil.

Diethylcarbamazine is utilized for heartworm prevention in canines.